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Life Extension, CR Mimetic Longevity Formula - 60 vegetarian capsules

  • $39.99
  • $34.99

The Best But how do you choose the very best nutritional supplements or even know what's in them? Our focus is on quality, purity, potency. Shouldn't that be your focus, too? Our quality control standards actually exceed FDA mandates. We source only the best raw materials for our nutritional supplements. Our products always give you the most nutritional potency for your dollar. We develop science-based supplements you simply won't find anywhere else.

CR Mimetic Longevity Formula mimics the anti-aging effects of calorie restrictionand triggers youthful gene expression. This comprehensive formula provides a powerful blend of six phytonutrients, including resveratrol, pterostilbene, quercetin, grape seed polyphenols, black tea extract, and fisetin, a natural fruit antioxidant. All these phytonutrients have been shown to generate many of the same effects in the body as caloric restriction, without significant dietary modification. In particular, they help mimic caloric restriction’s favorable impact on genes that influence the aging process. Get broad-spectrum support for youthful gene expression from scientifically validated phytonutrients in this comprehensive formulation.

Benefits at a Glance

  • Mimic the anti-aging effects of calorie restriction
  • Trigger youthful gene expression
  • Favorably impact genes that influence the aging process
  • Powerful blend of six anti-aging nutrients

Supports Healthy Metabolic Function†

  • Dietary Supplement
  • pTeroPure
  • Masquelier's

†This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Trigger Youthful Gene Expression

Life Extension® has gone to extraordinary lengths to identify those compounds that simulate calorie restriction’s ability to trigger youthful gene expression— the process by which genes transmit signals that slow certain aspects of aging. In 2003, we introduced standardized extract of resveratrol.

In 2009, we introduced the “other” resveratrol, pterostilbene, a compound whose effects were found to work in synergy with resveratrol to activate your “longevity genes.”

We’ve combined six known calorie restriction mimetics — trans-resveratrol, trans-pterostilbene, quercetin, grape seed polyphenols, black tea extract, and fisetin — in one, high-potency formula.1-9

The Original 5 – Powerful Phytonutrients for Living Longer

Trans-resveratrol is the form of resveratrol used in scientific studies documenting remarkable longevity enhancing effects. You would have to drink many bottles of red wine to obtain a fraction of the trans-resveratrol (250 mg) found in CR Mimetic Longevity Formula.

Trans-pterostilbene directly activates genes “downstream” from the sites of resveratrol’s action, providing a powerful complementary stimulus to resveratrol’s ability to induce youthful gene expression. You would have to eat 135 cups of blueberries to obtain the amount of trans-pterostilbene that is contained in CR Mimetic Longevity Formula.

Quercetin inhibits the actions of enzymes in the liver from rapidly breaking down resveratrol in the bloodstream, thus enabling resveratrol to remain active longer in the body.

Grape seed extract provides proanthocyanidins that have multiple health benefits and work together with resveratrol to trigger favorable gene expression changes. Theaflavins from black tea inhibit the pro-inflammatory transcription factor NF-kB10,11 and stimulate the longevity factor Forkhead box 1 (FOXO1) in invertebrate and mammalian cells.12 You would have to drink 12 six-ounce cups of black tea each day to obtain the amount of theaflavins contained in CR Mimetic Longevity Formula.

The Sixth CR Mimetic Discovered – Fisetin!

This innovative formulation features the little-known flavonoid fisetin (which is most abundantly found in strawberries). It is the sixth compound shown to simulate a youthful gene expression pattern similar to calorie restriction13 without significant dietary modification.

Fisetin may also enhance the effects of resveratrol.14 Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown14… thus extending its effects.

Fisetin has been shown to have the power to “switch on” powerful cell-signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.15 Fisetin also supports aging neurons in the presence of oxidative stress.15-17

And each serving of CR Mimetic Longevity Formula contains fisetin in an amount equivalent to 2 cups of strawberries, helping to further emulate calorie restriction’s favorable influence on your longevity genes.

Get the Longevity Benefits of Calorie Restriction without Restricting Calories

This unique formula provides cutting-edge broad-spectrum support for youthful gene expression from scientifically validated phytonutrients. Just two capsules a day of CR Mimetic Longevity Formula mimics the aging benefits of calorie restriction by triggering youthful gene expression — without restricting calories!

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.

Suggested Use Read the entire label and follow the directions carefully prior to use. Take two (2) capsules daily with or without food, or as recommended by a healthcare practitioner. Can be taken together or in divided doses.

Supplement Facts
Serving Size: 2 Vegetarian Capsules
Servings Per Container: 30
 Amount Per Serving% Daily Value
Trans-Resveratrol [from Japanese knotweed extract (root)]250 mg**
Trans-Pterostilbene (from pTeroPure)3 mg**
Quercetin (as quercetin dihydrate)150 mg**
Masquelier's Original OPCs [single and condensed (2-5 units) of flavonols & polyphenols from grape seeds]50 mg**
Black tea decaffeinated extract (leaf) [providing 36 mg TF2a theaflavin fraction]300 mg**
Fisetin [from wax tree extract (stem)]48 mg**
**Daily Value not established.

Other Ingredients

Vegetable cellulose (capsule), microcrystalline cellulose, silica, vegetable stearate.


Caution: Consult with your doctor before using this product if you have a bleeding disorder, or if you are taking anticoagulant, antiplatelet, or diabetic medications.

Store tightly closed in a cool, dry place.

  • Keep out of reach of children.
  • Do not exceed recommended dose.
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

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